The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Evidence has emerged that the failing heart increases utilization of ketone bodies. We sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing the ketone body 3-hydroxybutyrate (3OHB) in the heart exhibited worsened heart failure in response to fasting or a pres...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Horton, Julie L., Davidson, Michael T., Kurishima, Clara, Vega, Rick B., Powers, Jeffery C., Matsuura, Timothy R., Petucci, Christopher, Lewandowski, E. Douglas, Crawford, Peter A., Muoio, Deborah M., Recchia, Fabio A., Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478419/
https://ncbi.nlm.nih.gov/pubmed/30668551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124079
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