The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Evidence has emerged that the failing heart increases utilization of ketone bodies. We sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing the ketone body 3-hydroxybutyrate (3OHB) in the heart exhibited worsened heart failure in response to fasting or a pres...

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Publicado en:JCI Insight
Main Authors: Horton, Julie L., Davidson, Michael T., Kurishima, Clara, Vega, Rick B., Powers, Jeffery C., Matsuura, Timothy R., Petucci, Christopher, Lewandowski, E. Douglas, Crawford, Peter A., Muoio, Deborah M., Recchia, Fabio A., Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478419/
https://ncbi.nlm.nih.gov/pubmed/30668551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124079
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