Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells

Abnormal activation of neddylation modification and dysregulated energy metabolism are frequently seen in many types of cancer cells. Whether and how neddylation modification affects cellular metabolism remains largely unknown. Here, we showed that MLN4924, a small-molecule inhibitor of neddylation...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Zhou, Qiyin, Li, Hua, Li, Yuanyuan, Tan, Mingjia, Fan, Shaohua, Cao, Cong, Meng, Feilong, Zhu, Ling, Zhao, Lili, Guan, Min-Xin, Jin, Hongchuan, Sun, Yi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478410/
https://ncbi.nlm.nih.gov/pubmed/30668548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121582
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