Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells

Abnormal activation of neddylation modification and dysregulated energy metabolism are frequently seen in many types of cancer cells. Whether and how neddylation modification affects cellular metabolism remains largely unknown. Here, we showed that MLN4924, a small-molecule inhibitor of neddylation...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Zhou, Qiyin, Li, Hua, Li, Yuanyuan, Tan, Mingjia, Fan, Shaohua, Cao, Cong, Meng, Feilong, Zhu, Ling, Zhao, Lili, Guan, Min-Xin, Jin, Hongchuan, Sun, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478410/
https://ncbi.nlm.nih.gov/pubmed/30668548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121582
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