Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells

Abnormal activation of neddylation modification and dysregulated energy metabolism are frequently seen in many types of cancer cells. Whether and how neddylation modification affects cellular metabolism remains largely unknown. Here, we showed that MLN4924, a small-molecule inhibitor of neddylation...

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Vydáno v:JCI Insight
Hlavní autoři: Zhou, Qiyin, Li, Hua, Li, Yuanyuan, Tan, Mingjia, Fan, Shaohua, Cao, Cong, Meng, Feilong, Zhu, Ling, Zhao, Lili, Guan, Min-Xin, Jin, Hongchuan, Sun, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478410/
https://ncbi.nlm.nih.gov/pubmed/30668548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121582
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