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Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses

The DNA repair enzyme ALKBH2 is implicated in both tumorigenesis as well as resistance to chemotherapy in certain cancers. It is currently under study as a potential diagnostic marker and has been proposed as a therapeutic target. To date, however, there exist no direct methods for measuring the rep...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Wilson, David L., Beharry, Andrew A., Srivastava, Avinash, O’Connor, Timothy R., Kool, Eric T.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478024/
https://ncbi.nlm.nih.gov/pubmed/30098084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201807593
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