Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

The TCL1 mouse model is widely used to study pathophysiology, clonal evolution, and drug sensitivity or resistance of chronic lymphocytic leukemia (CLL). By performing whole exome sequencing, we present the genetic landscape of primary tumors from TCL1 mice and of TCL1 tumors serially transplanted i...

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Опубликовано в: :Leukemia
Главные авторы: Zaborsky, Nadja, Gassner, Franz J., Höpner, Jan P., Schubert, Maria, Hebenstreit, Daniel, Stark, Richard, Asslaber, Daniela, Steiner, Markus, Geisberger, Roland, Greil, Richard, Egle, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477797/
https://ncbi.nlm.nih.gov/pubmed/30262843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0260-4
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