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Lysine Residue at Position 22 of the AID Protein Regulates Its Class Switch Activity
BACKGROUND: Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have evolved, including...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3282692/ https://ncbi.nlm.nih.gov/pubmed/22363466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030667 |
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