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Lysine Residue at Position 22 of the AID Protein Regulates Its Class Switch Activity
BACKGROUND: Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have evolved, including...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3282692/ https://ncbi.nlm.nih.gov/pubmed/22363466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030667 |
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