Lysine Residue at Position 22 of the AID Protein Regulates Its Class Switch Activity

BACKGROUND: Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have evolved, including...

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Detaylı Bibliyografya
Asıl Yazarlar: Geisberger, Roland, Huemer, Michael, Gassner, Franz J., Zaborsky, Nadja, Egle, Alexander, Greil, Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282692/
https://ncbi.nlm.nih.gov/pubmed/22363466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030667
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