MEDU-46. SONIC HEDGEHOG SPEEDS UP DNA REPLICATION AND CAUSES CANCER-INITIATING MUTATIONS

Cancer is a multi-stage disease caused by sequential mutations; however, the molecular mechanism that generates cancer-initiating mutations is not well understood. Using the developing cerebellum as a model system, here we show the molecular mechanism of tumor initiation in Sonic hedgehog medullobla...

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Vydáno v:Neuro Oncol
Hlavní autoři: Tamayo-Orrego, Lukas, Gallo, David, Bemmo, Amandine, Mohan, Sushmetha, Salameh, Samer, Racicot, Frederic, Brown, Grant, Charron, Frederic
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Medulloblastoma
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477353/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.204
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