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THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA
BACKGROUND: Glioblastoma (GBM) has dysregulated signaling of the mTOR pathway. Rapalink-1, a bivalent inhibitor created by linking rapamycin and sapanisertib, can bind to both drug binding pockets, potently inhibits mTORC1 in vitro and in vivo. Although Rapalink-1 represents a novel path towards mTO...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477344/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.215 |
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