THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA

BACKGROUND: Glioblastoma (GBM) has dysregulated signaling of the mTOR pathway. Rapalink-1, a bivalent inhibitor created by linking rapamycin and sapanisertib, can bind to both drug binding pockets, potently inhibits mTORC1 in vitro and in vivo. Although Rapalink-1 represents a novel path towards mTO...

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Udgivet i:Neuro Oncol
Main Authors: Luo, Xujun, Fan, Qi-Wen, Shokat, Kevan M, Weiss, William A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477344/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.215
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