Betacellulin drives therapy resistance in glioblastoma

BACKGROUND: The transcription factor signal transducer and activator of transcription 3 (STAT3) drives progression in glioblastoma (GBM), suggesting STAT3 as a therapeutic target. Surprisingly however, GBM cells generally show primary resistance to STAT3 blockade. METHODS: Human glioblastoma cell li...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Fan, Qiwen, An, Zhenyi, Wong, Robyn A, Luo, Xujun, Lu, Edbert D, Baldwin, Albert, Mayekar, Manasi K, Haderk, Franziska, Shokat, Kevan M, Bivona, Trever G, Weiss, William A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158663/
https://ncbi.nlm.nih.gov/pubmed/31678994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz206
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