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ATRT-02. THERAPEUTIC TARGETING OF EZH2 AND BET BRD4 IN AT/RT
Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal childhood cancers and defined by inactivation of the SMARCB1 tumor suppressor gene encoding a chromatin remodeling complex which suppresses activity of EZH2 methyltransferase. The absence of SMARCB1 protein promotes increased EZH2 activity, resul...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477262/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.001 |
| タグ: |
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