ATRT-02. THERAPEUTIC TARGETING OF EZH2 AND BET BRD4 IN AT/RT

Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal childhood cancers and defined by inactivation of the SMARCB1 tumor suppressor gene encoding a chromatin remodeling complex which suppresses activity of EZH2 methyltransferase. The absence of SMARCB1 protein promotes increased EZH2 activity, resul...

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Vydáno v:Neuro Oncol
Hlavní autoři: Zhang, Ali, Piunti, Andrea, Ozark, Patrick, He, Xingyao, Katagi, Hiroaki, Sasaki, Takahiro, Laurie, Kathryn, Goldman, Stewart, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Atypical Teratoid Rhabdoid Tumor (ATRT)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477262/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.001
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