MEDU-16. MYC BUT NOT MYCN GENERATES AGGRESSIVE GROUP 3 MEDULLOBLASTOMA THROUGH ARF SUPPRESSION

Group 3 medulloblastoma (MB) carry the worst prognosis of all MB. The transcription factors MYC and MYCN are suggested drivers for a subset of these tumours; with MYC amplifications (17–20%) representing the most common genetic alteration in Group 3 tumours, while MYCN amplifications (4–6%) are less...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Mainwaring, Oliver, Weishaupt, Holger, Hutter, Sonja, Rosen, Gabriela, Annusver, Karl, Kasper, Maria, Swartling, Fredrik
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Medulloblastoma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477231/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.175
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