THER-11. BMI-1 MODULATION IMPAIRS DNA DAMAGE RESPONSE AND SENSITIZES DIPG CELLS TO IONIZING RADIATION

Diffuse intrinsic pontine glioma (DIPG) is a poor-prognosis brain tumor with no effective curative therapy. We previously identified BMI-1 as a potential therapeutic target in DIPG*. We have shown that BMI-1 is highly expressed in DIPG tumors and patient-derived cells regardless of histone subtype....

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Kumar, Shiva Senthil, Sengupta, Satarupa, Weetall, Marla, Baird, John, Drissi, Rachid
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477219/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.218
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