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DIPG-18. SONIC HEDGEHOG (SHH) SIGNALLING PROMOTES BLOOD BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
DIPG is the most common brainstem tumor in children and is uniformly fatal. The BBB is intact in DIPG and plays an active role in restricting the delivery of systemically administered therapies into the tumor. Recent studies have shown that SHH signalling plays a major role in the maintenance of BBB...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477213/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.039 |
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