DIPG-18. SONIC HEDGEHOG (SHH) SIGNALLING PROMOTES BLOOD BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

DIPG is the most common brainstem tumor in children and is uniformly fatal. The BBB is intact in DIPG and plays an active role in restricting the delivery of systemically administered therapies into the tumor. Recent studies have shown that SHH signalling plays a major role in the maintenance of BBB...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Sajesh, Babu, On, Ngoc, Donald, Miller, Kazina, Colin, Serletis, Demitre, Del-Bigio, Marc, Krawitz, Sherry, Hulleman, Esther, Vanan, Magimairajan Issai
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Diffuse Intrinsic Pontine Glioma (DIPG)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477213/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.039
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