Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multi-Drug Resistance Proteins

Our laboratories have been investigating synthetic analogues of marine alkaloid rigidins possessing promising anticancer activities. These analogues, based on the 7-deazahypoxanthine skeleton are available in one- or two-step synthetic sequences and exert cytotoxicity by disrupting microtubule dynam...

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Vydáno v:ChemMedChem
Hlavní autoři: Dasari, Ramesh, Błauż, Andrzej, Medellin, Derek C., Kassim, Roaa M., Viera, Carlos, Santarosa, Maximo, Turner, Danielle, van der Westhuyzen, Alet E., van Otterlo, Willem A. L., Olivas, Taryn, Yildiz, Tugba, Betancourt, Tania, Shuster, Charles B., Rogelj, Snezna, Rychlik, Błażej, Hudnall, Todd, Frolova, Liliya V., Kornienko, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476547/
https://ncbi.nlm.nih.gov/pubmed/30562414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800658
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