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Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multi-Drug Resistance Proteins

Our laboratories have been investigating synthetic analogues of marine alkaloid rigidins possessing promising anticancer activities. These analogues, based on the 7-deazahypoxanthine skeleton are available in one- or two-step synthetic sequences and exert cytotoxicity by disrupting microtubule dynam...

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Bibliografske podrobnosti
izdano v:ChemMedChem
Main Authors: Dasari, Ramesh, Błauż, Andrzej, Medellin, Derek C., Kassim, Roaa M., Viera, Carlos, Santarosa, Maximo, Turner, Danielle, van der Westhuyzen, Alet E., van Otterlo, Willem A. L., Olivas, Taryn, Yildiz, Tugba, Betancourt, Tania, Shuster, Charles B., Rogelj, Snezna, Rychlik, Błażej, Hudnall, Todd, Frolova, Liliya V., Kornienko, Alexander
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476547/
https://ncbi.nlm.nih.gov/pubmed/30562414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800658
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