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Rapid screening of lanthipeptide analogs via in-colony removal of leader peptides in Escherichia coli

Most native producers of ribosomally synthesized and post-translationally modified peptides (RiPPs) utilize N-terminal leader peptides to avoid potential cytotoxicity of mature products to the hosts. Unfortunately, the native machinery of leader peptide removal is often difficult to reconstitute in...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Si, Tong, Tian, Qiqi, Min, Yuhao, Zhang, Linzixuan, Sweedler, Jonathan V., van der Donk, Wilfred A., Zhao, Huimin
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476326/
https://ncbi.nlm.nih.gov/pubmed/30183279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05544
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