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Rapid screening of lanthipeptide analogs via in-colony removal of leader peptides in Escherichia coli
Most native producers of ribosomally synthesized and post-translationally modified peptides (RiPPs) utilize N-terminal leader peptides to avoid potential cytotoxicity of mature products to the hosts. Unfortunately, the native machinery of leader peptide removal is often difficult to reconstitute in...
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| Published in: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6476326/ https://ncbi.nlm.nih.gov/pubmed/30183279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05544 |
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