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pH dependent conformational dynamics of Beta-secretase 1: a molecular dynamics study
Beta-secretase 1 (BACE-1) is an aspartyl protease implicated in the overproduction of β-amyloid fibrils responsible for Alzheimer’s disease. The process of β-amyloid genesis is known to be pH dependent, with an activity peak between solution pH of 3.5 and 5.5. We have studied the pH dependent dynami...
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| Publicado en: | J Mol Recognit |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6476308/ https://ncbi.nlm.nih.gov/pubmed/30264484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2765 |
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