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The pH-Dependent Conformational States of Kyotorphin: A Constant-pH Molecular Dynamics Study

An extensive conformational study of the analgesic dipeptide kyotorphin (L-Tyr-L-Arg) at different pH values was performed using a constant-pH molecular dynamics method. This dipeptide showed a remarkable pH-dependent conformational variety. The protonation of the N-terminal amine was identified as...

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Detalhes bibliográficos
Main Authors: Machuqueiro, Miguel, Baptista, António M.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1861802/
https://ncbi.nlm.nih.gov/pubmed/17172294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092445
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