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Protocols Utilizing Constant pH Molecular Dynamics to Compute pH-Dependent Binding Free Energies

[Image: see text] In protein–ligand binding, the electrostatic environments of the two binding partners may vary significantly in bound and unbound states, which may lead to protonation changes upon binding. In cases where ligand binding results in a net uptake or release of protons, the free energy...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Kim, M. Olivia, Blachly, Patrick G., Kaus, Joseph W., McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306499/
https://ncbi.nlm.nih.gov/pubmed/25134690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp505777n
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