Native-state conformational dynamics of GART: A regulatory pH-dependent coil–helix transition examined by electrostatic calculations

Glycinamide ribonucleotide transformylase (GART) undergoes a pH-dependent coil–helix transition with pK(a) ∼ 7. An α-helix is formed at high pH spanning 8 residues of a 21-residue-long loop, comprising the segment Thr120–His121–Arg122–Gln123–Ala124–Leu125–Glu126–Asn127. To understand the electrostat...

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Xehetasun bibliografikoak
Egile Nagusiak: Morikis, Dimitrios, Elcock, Adrian H., Jennings, Patricia A., McCammon, J. Andrew
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2001
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374060/
https://ncbi.nlm.nih.gov/pubmed/11604542
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