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Native-state conformational dynamics of GART: A regulatory pH-dependent coil–helix transition examined by electrostatic calculations
Glycinamide ribonucleotide transformylase (GART) undergoes a pH-dependent coil–helix transition with pK(a) ∼ 7. An α-helix is formed at high pH spanning 8 residues of a 21-residue-long loop, comprising the segment Thr120–His121–Arg122–Gln123–Ala124–Leu125–Glu126–Asn127. To understand the electrostat...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374060/ https://ncbi.nlm.nih.gov/pubmed/11604542 |
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