HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness

Human immunodeficiency virus type 1 subtype C (HIV-1C) has a natural deletion of a YPxL motif in its Gag-p6 late domain. This domain mediates the binding of Gag to host cell protein ALIX and subsequently facilitates viral budding. In a subset of HIV-1C-infected individuals, the tetrapeptide insertio...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: van Domselaar, Robert, Njenda, Duncan T., Rao, Rohit, Sönnerborg, Anders, Singh, Kamalendra, Neogi, Ujjwal
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475790/
https://ncbi.nlm.nih.gov/pubmed/30760577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00077-19
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