Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region which is appears in protease inhibitor (PI) failure Indian HIV-1C sequences (Odds Ratio 17.1, p<0.001) but naturally present in half of untreated Ethiopian sequences. The insertion will probably restore the ALIX mediated...

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Autores principales: Neogi, Ujjwal, RAO, Shwetha D, BONTELL, Irene, VERHEYEN, Jens, RAO, Vasudev R, GORE, Sagar C, SONI, Neelesh, SHET, Anita, SCHÜLTER, Eugen, EKSTRAND, Maria L., WONDWOSSEN, Amogne, KAISER, Rolf, MADHUSUDHAN, Mallur S., PRASAD, Vinayaka R, SONNERBORG, Anders
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198440/
https://ncbi.nlm.nih.gov/pubmed/25102091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000419
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