CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

Cellular ESCRT machinery plays pivotal role in HIV-1 budding and release. Extracellular stimuli that modulate HIV-1 egress are currently unknown. We found that CCL2 induced by HIV-1 clade B (HIV-1B) infection of macrophages enhanced virus production, while CCL2 immuno-depletion reversed this effect....

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Ajasin, David O, Rao, Vasudev R, Wu, Xuhong, Ramasamy, Santhamani, Pujato, Mario, Ruiz, Arthur P, Fiser, Andras, Bresnick, Anne R, Kalpana, Ganjam V, Prasad, Vinayaka R
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Microbiology and Infectious Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592687/
https://ncbi.nlm.nih.gov/pubmed/31172941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35546
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