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Antiretroviral potency of 4′-ethnyl-2′-fluoro-2′-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes
OBJECTIVES: 4′-Ethnyl-2′-fluoro-2′-deoxyadenosine (EFdA) is a novel translocation-defective reverse transcriptase inhibitor. We investigated the virological and biochemical inhibitory potentials of EFdA against a broad spectrum of subtype-specific chimeric viruses and compared it with tenofovir alaf...
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| Veröffentlicht in: | J Antimicrob Chemother |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148215/ https://ncbi.nlm.nih.gov/pubmed/30053052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky256 |
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