Antiretroviral potency of 4′-ethnyl-2′-fluoro-2′-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes

OBJECTIVES: 4′-Ethnyl-2′-fluoro-2′-deoxyadenosine (EFdA) is a novel translocation-defective reverse transcriptase inhibitor. We investigated the virological and biochemical inhibitory potentials of EFdA against a broad spectrum of subtype-specific chimeric viruses and compared it with tenofovir alaf...

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Vydáno v:J Antimicrob Chemother
Hlavní autoři: Njenda, Duncan T, Aralaguppe, Shambhu G, Singh, Kamalendra, Rao, Rohit, Sönnerborg, Anders, Sarafianos, Stefan G, Neogi, Ujjwal
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148215/
https://ncbi.nlm.nih.gov/pubmed/30053052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky256
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