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Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells

When expressed in tobacco cells, the catalytic subunit of the dimeric ribosome inactivating protein, ricin, is first inserted into the endoplasmic reticulum (ER) and then degraded in a manner that can be partially inhibited by the proteasome inhibitor clasto-lactacystin β-lactone. Consistent with th...

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Autori principali: Di Cola, Alessandra, Frigerio, Lorenzo, Lord, J. Michael, Ceriotti, Aldo, Roberts, Lynne M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC64749/
https://ncbi.nlm.nih.gov/pubmed/11734657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251386098
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