Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling

Alzheimer’s disease (AD) is characterized by the accumulation of neurotoxic amyloid-β (Aβ) peptides consisting of 39-43 amino acids, proteolytically derived fragments of the amyloid-β protein precursor (AβPP), and the accumulation of the hyperphosphorylated microtubule-associated protein tau. Inhibi...

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Publicado en:J Alzheimers Dis
Main Authors: Chen, Ci-Di, Zeldich, Ella, Khodr, Christina, Camara, Kaddy, Tung, Tze Yu, Lauder, Emma C., Mullen, Patrick, Polanco, Taryn J., Liu, Yen-Yu, Zeldich, Dean, Xia, Weiming, Van Nostrand, William E., Brown, Lauren E., Porco, John A., Abraham, Carmela R.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474660/
https://ncbi.nlm.nih.gov/pubmed/30776010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-180923
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