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N-Acyl pyrazoles: effective and tunable inhibitors of serine hydrolases
A series of N-acyl pyrazoles was examined as candidate serine hydrolase inhibitors in which the active site acylating reactivity and the leaving group ability of the pyrazole could be tuned not only through the nature of the acyl group (reactivity: amide > carbamate > urea), but also through p...
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| Veröffentlicht in: | Bioorg Med Chem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6474344/ https://ncbi.nlm.nih.gov/pubmed/30879861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.03.020 |
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