Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells

PURPOSE: Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric cancer. AZD1208 is a potent and selective inhibitor that affects all three isoforms...

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Bibliografiske detaljer
Udgivet i:Cancer Res Treat
Main Authors: Lee, Miso, Lee, Kyung-Hun, Min, Ahrum, Kim, Jeongeun, Kim, Seongyeong, Jang, Hyemin, Lim, Jee Min, Kim, So Hyeon, Ha, Dong-Hyeon, Jeong, Won Jae, Suh, Koung Jin, Yang, Yae-Won, Kim, Tae Yong, Oh, Do-Youn, Bang, Yung-Jue, Im, Seock-Ah
Format: Artigo
Sprog:Inglês
Udgivet: Korean Cancer Association 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6473293/
https://ncbi.nlm.nih.gov/pubmed/29879757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2017.341
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