RNA binding antagonizes neurotoxic phase transitions of TDP-43.

TDP-43 proteinopathy is a pathological hallmark of ALS/FTD where cytoplasmic TDP-43 inclusions are observed within degenerating regions of patient postmortem tissue. The mechanism by which TDP-43 aggregates has remained elusive due to technological limitations which prevent the analysis of specific...

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Bibliografiska uppgifter
I publikationen:Neuron
Huvudupphovsmän: Mann, Jacob R., Gleixner, Amanda M., Mauna, Jocelyn C., Gomes, Edward, DeChellis-Marks, Michael R., Needham, Patrick G., Copley, Katie E., Hurtle, Bryan, Portz, Bede, Pyles, Noah J., Guo, Lin, Calder, Christopher B., Wills, Zachary P., Pandey, Udai B., Kofler, Julia K., Brodsky, Jeffrey L., Thathiah, Amantha, Shorter, James, Donnelly, Christopher J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472983/
https://ncbi.nlm.nih.gov/pubmed/30826182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.048
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