RNA binding antagonizes neurotoxic phase transitions of TDP-43.

TDP-43 proteinopathy is a pathological hallmark of ALS/FTD where cytoplasmic TDP-43 inclusions are observed within degenerating regions of patient postmortem tissue. The mechanism by which TDP-43 aggregates has remained elusive due to technological limitations which prevent the analysis of specific...

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Publicado no:Neuron
Main Authors: Mann, Jacob R., Gleixner, Amanda M., Mauna, Jocelyn C., Gomes, Edward, DeChellis-Marks, Michael R., Needham, Patrick G., Copley, Katie E., Hurtle, Bryan, Portz, Bede, Pyles, Noah J., Guo, Lin, Calder, Christopher B., Wills, Zachary P., Pandey, Udai B., Kofler, Julia K., Brodsky, Jeffrey L., Thathiah, Amantha, Shorter, James, Donnelly, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472983/
https://ncbi.nlm.nih.gov/pubmed/30826182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.048
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