Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in microtubules. Here, we used covalent taxane-site ligands, inclu...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Balaguer, Francisco de Asís, Mühlethaler, Tobias, Estévez-Gallego, Juan, Calvo, Enrique, Giménez-Abián, Juan Francisco, Risinger, April L., Sorensen, Erik J., Vanderwal, Christopher D., Altmann, Karl-Heinz, Mooberry, Susan L., Steinmetz, Michel O., Oliva, María Ángela, Prota, Andrea E., Díaz, J. Fernando
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471726/
https://ncbi.nlm.nih.gov/pubmed/30897704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061392
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