CYCLOSTREPTIN DERIVATIVES SPECIFICALLY TARGET CELLULAR TUBULIN AND FURTHER MAP THE PACLITAXEL SITE

Cyclostreptin is the first microtubule stabilizing agent whose mechanism of action was discovered to involve formation of a covalent bond with tubulin. Treatment of cells with cyclostreptin irreversibly stabilizes their microtubules because cyclostreptin forms a covalent bond to β-tubulin at either...

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Detalhes bibliográficos
Main Authors: Calvo, Enrique, Barasoain, Isabel, Matesanz, Ruth, Pera, Benet, Camafeita, Emilio, Pineda, Oriol, Hamel, Ernest, Vanderwal, Christopher D., Andreu, José Manuel, López, Juan A., Díaz, José Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255483/
https://ncbi.nlm.nih.gov/pubmed/22148836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201380p
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