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Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study
We have synthesized quinoxaline analogs (1–25), characterized by (1)H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC(50) = 38.68 ± 4.42 µM). The most poten...
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| Izdano u: | Molecules |
|---|---|
| Glavni autori: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6471342/ https://ncbi.nlm.nih.gov/pubmed/30871147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24061002 |
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