Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study

We have synthesized quinoxaline analogs (1–25), characterized by (1)H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC(50) = 38.68 ± 4.42 µM). The most poten...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Molecules
Glavni autori: Almandil, Noor Barak, Taha, Muhammad, Farooq, Rai Khalid, Alhibshi, Amani, Ibrahim, Mohamed, Anouar, El Hassane, Gollapalli, Mohammed, Rahim, Fazal, Nawaz, Muhammad, Shah, Syed Adnan Ali, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471342/
https://ncbi.nlm.nih.gov/pubmed/30871147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24061002
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items