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Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study
Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC(50) values ranging between 0.5 ± 0.08 to 38.9 ± 0.8 µM when compared with standard d-sacchari...
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| Publicado no: | BMC Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6661955/ https://ncbi.nlm.nih.gov/pubmed/31384763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-019-0522-x |
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