Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC(50) values ranging between 0.5 ± 0.08 to 38.9 ± 0.8 µM when compared with standard d-sacchari...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Chem
Main Authors: Almandil, Noor Barak, Taha, Muhammad, Gollapalli, Mohammed, Rahim, Fazal, Ibrahim, Mohamed, Mosaddik, Ashik, Anouar, El Hassane
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6661955/
https://ncbi.nlm.nih.gov/pubmed/31384763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-019-0522-x
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