Interrogating PP1 Activity in the MAPK Pathway with Optimized PP1‐Disrupting Peptides

Protein phosphatase‐1 (PP1)‐disrupting peptides (PDPs) are selective chemical modulators of PP1 that liberate the active PP1 catalytic subunit from regulatory proteins; thus allowing the dephosphorylation of nearby substrates. We have optimized the original cell‐active PDP3 for enhanced stability, a...

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Foilsithe in:Chembiochem
Main Authors: Wang, Yansong, Hoermann, Bernhard, Pavic, Karolina, Trebacz, Malgorzata, Rios, Pablo, Köhn, Maja
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2018
Ábhair:
Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471087/
https://ncbi.nlm.nih.gov/pubmed/30338897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800541
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