Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola virus, Sudan virus and Bundibugyo virus. Monoclonal antibody (mAb) cocktails against the surface glycoprotein (GP) present a potential therapeutic strategy. Here we report two crystal structures of the antibody...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: King, Liam B., West, Brandyn R., Moyer, Crystal L., Gilchuk, Pavlo, Flyak, Andrew, Ilinykh, Philipp A., Bombardi, Robin, Hui, Sean, Huang, Kai, Bukreyev, Alexander, Crowe, James E., Saphire, Erica Ollmann
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470140/
https://ncbi.nlm.nih.gov/pubmed/30996276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09732-7
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