Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola virus, Sudan virus and Bundibugyo virus. Monoclonal antibody (mAb) cocktails against the surface glycoprotein (GP) present a potential therapeutic strategy. Here we report two crystal structures of the antibody...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: King, Liam B., West, Brandyn R., Moyer, Crystal L., Gilchuk, Pavlo, Flyak, Andrew, Ilinykh, Philipp A., Bombardi, Robin, Hui, Sean, Huang, Kai, Bukreyev, Alexander, Crowe, James E., Saphire, Erica Ollmann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470140/
https://ncbi.nlm.nih.gov/pubmed/30996276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09732-7
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