Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

Designer receptors exclusively activated by designer drugs (DREADDs) derived from muscarinic receptors not only are a powerful tool to test causality in basic neuroscience but also are potentially amenable to clinical translation. A major obstacle, however, is that the widely used agonist clozapine...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Weston, Mikail, Kaserer, Teresa, Wu, Angela, Mouravlev, Alexandre, Carpenter, Jenna C., Snowball, Albert, Knauss, Samuel, von Schimmelmann, Melanie, During, Matthew J., Lignani, Gabriele, Schorge, Stephanie, Young, Deborah, Kullmann, Dimitri M., Lieb, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469940/
https://ncbi.nlm.nih.gov/pubmed/31001591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw1567
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