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DREADD: A Chemogenetic GPCR Signaling Platform

Recently, we created a family of engineered G protein-coupled receptors (GPCRs) called DREADD (designer receptors exclusively activated by designer drugs) which can precisely control three major GPCR signaling pathways (Gq, Gi, and Gs). DREADD technology has been successfully applied in a variety of...

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Bibliographic Details
Published in:Int J Neuropsychopharmacol
Main Authors: Zhu, Hu, Roth, Bryan L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368861/
https://ncbi.nlm.nih.gov/pubmed/25522378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu007
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