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Silencing synapses with DREADDs
In this issue, Stachniak et al. determine that the chemogenetic silencer, hM4Di-DREADD, suppresses presynaptic glutamate release and by generating an axon targeted hM4Di variant they demonstrate it can be used to locally silence synaptic transmission in neural circuits.
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109642/ https://ncbi.nlm.nih.gov/pubmed/24853931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.05.002 |
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