In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

Epilepsy is a major health burden, calling for new mechanistic insights and therapies. CRISPR-mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex vivo. Its translational potential for treating non-genetic pathologies is still unexplored. F...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Colasante, Gaia, Qiu, Yichen, Massimino, Luca, Di Berardino, Claudia, Cornford, Jonathan H, Snowball, Albert, Weston, Mikail, Jones, Steffan P, Giannelli, Serena, Lieb, Andreas, Schorge, Stephanie, Kullmann, Dimitri M, Broccoli, Vania, Lignani, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089667/
https://ncbi.nlm.nih.gov/pubmed/32129831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa045
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