CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Tumor–stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated fibroblasts (CAFs) and mast cells (MC) affected the sensitivity of PDAC cells to gemcitabine/nabpaclitaxel (GEM/NAB). For this purpose, the co...

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Publicado en:Cancers (Basel)
Autores principales: Porcelli, Letizia, Iacobazzi, Rosa Maria, Di Fonte, Roberta, Serratì, Simona, Intini, Angelica, Solimando, Antonio Giovanni, Brunetti, Oronzo, Calabrese, Angela, Leonetti, Francesco, Azzariti, Amalia, Silvestris, Nicola
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468868/
https://ncbi.nlm.nih.gov/pubmed/30866547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030330
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