CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Tumor–stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated fibroblasts (CAFs) and mast cells (MC) affected the sensitivity of PDAC cells to gemcitabine/nabpaclitaxel (GEM/NAB). For this purpose, the co...

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Publicat a:Cancers (Basel)
Autors principals: Porcelli, Letizia, Iacobazzi, Rosa Maria, Di Fonte, Roberta, Serratì, Simona, Intini, Angelica, Solimando, Antonio Giovanni, Brunetti, Oronzo, Calabrese, Angela, Leonetti, Francesco, Azzariti, Amalia, Silvestris, Nicola
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468868/
https://ncbi.nlm.nih.gov/pubmed/30866547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030330
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