CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Tumor–stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated fibroblasts (CAFs) and mast cells (MC) affected the sensitivity of PDAC cells to gemcitabine/nabpaclitaxel (GEM/NAB). For this purpose, the co...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Porcelli, Letizia, Iacobazzi, Rosa Maria, Di Fonte, Roberta, Serratì, Simona, Intini, Angelica, Solimando, Antonio Giovanni, Brunetti, Oronzo, Calabrese, Angela, Leonetti, Francesco, Azzariti, Amalia, Silvestris, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468868/
https://ncbi.nlm.nih.gov/pubmed/30866547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030330
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