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Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy

Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas, fibrosarcoma, and other cancers leads to a novel metabolite, D-2-hydroxyglutarate, which is proposed to cause tumorigenesis. The production of this metabolite also causes vulnerabilities in cellular metabolism, such as lowering NADPH levels. To...

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Detalhes bibliográficos
Publicado no:Biosensors (Basel)
Main Authors: Larion, Mioara, Dowdy, Tyrone, Ruiz-Rodado, Victor, Meyer, Matthew W., Song, Hua, Zhang, Wei, Davis, Dionne, Gilbert, Mark R., Lita, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468689/
https://ncbi.nlm.nih.gov/pubmed/30597885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/bios9010005
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