Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression

Neuropathic pain is a worldwide health concern with poor treatment outcomes. Accumulating evidence suggests that histone hypoacetylation is involved in development and maintenance of neuropathic pain. Thus, many natural and synthetic histone deacetylase (HDACs) inhibitors were tested and exhibited a...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Ouyang, Bihan, Chen, Dan, Hou, Xinran, Wang, Tongxuan, Wang, Jian, Zou, Wangyuan, Song, Zongbin, Huang, Changsheng, Guo, Qulian, Weng, Yingqi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468568/
https://ncbi.nlm.nih.gov/pubmed/31024248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00346
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